Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model

Fragile X syndrome (FXS), caused by the loss of functional FMRP, is a leading cause of autism. Neurons lacking FMRP show aberrant mRNA translation and intracellular signalling. Here, we identify that, in Fmr1 knockout neurons, type 1 adenylyl cyclase (Adcy1) mRNA translation is enhanced, leading to...

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Detalles Bibliográficos
Autores principales: Sethna, Ferzin, Feng, Wei, Ding, Qi, Robison, Alfred J., Feng, Yue, Wang, Hongbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321753/
https://www.ncbi.nlm.nih.gov/pubmed/28218269
http://dx.doi.org/10.1038/ncomms14359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321753/
https://www.ncbi.nlm.nih.gov/pubmed/28218269
http://dx.doi.org/10.1038/ncomms14359

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