Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation

Protein disulfide isomerase (PDI), secreted by platelets and endothelial cells on vascular injury, is required for thrombus formation. Using PDI variants that form mixed disulfide complexes with their substrates, we identify by kinetic trapping multiple substrate proteins, including vitronectin. Pla...

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Detalles Bibliográficos
Autores principales: Bowley, Sheryl R., Fang, Chao, Merrill-Skoloff, Glenn, Furie, Barbara C., Furie, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321760/
https://www.ncbi.nlm.nih.gov/pubmed/28218242
http://dx.doi.org/10.1038/ncomms14151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321760/
https://www.ncbi.nlm.nih.gov/pubmed/28218242
http://dx.doi.org/10.1038/ncomms14151

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