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Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation
Protein disulfide isomerase (PDI), secreted by platelets and endothelial cells on vascular injury, is required for thrombus formation. Using PDI variants that form mixed disulfide complexes with their substrates, we identify by kinetic trapping multiple substrate proteins, including vitronectin. Pla...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321760/ https://www.ncbi.nlm.nih.gov/pubmed/28218242 http://dx.doi.org/10.1038/ncomms14151 |