STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate

Store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels constitute a major pathway for Ca(2+) influx and mediate many essential signalling functions in animal cells, yet how they open remains elusive. Here, we investigate the gating mechanism of the human CRAC channel Orai1 by its activator,...

Descripción completa

Detalles Bibliográficos
Autores principales: Yamashita, Megumi, Yeung, Priscilla S.-W., Ing, Christopher E., McNally, Beth A., Pomès, Régis, Prakriya, Murali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321763/
https://www.ncbi.nlm.nih.gov/pubmed/28220789
http://dx.doi.org/10.1038/ncomms14512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321763/
https://www.ncbi.nlm.nih.gov/pubmed/28220789
http://dx.doi.org/10.1038/ncomms14512

Ejemplares similares