Cargando…

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate

Store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels constitute a major pathway for Ca(2+) influx and mediate many essential signalling functions in animal cells, yet how they open remains elusive. Here, we investigate the gating mechanism of the human CRAC channel Orai1 by its activator,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yamashita, Megumi, Yeung, Priscilla S.-W., Ing, Christopher E., McNally, Beth A., Pomès, Régis, Prakriya, Murali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321763/ https://www.ncbi.nlm.nih.gov/pubmed/28220789 http://dx.doi.org/10.1038/ncomms14512

Ejemplares similares

Gated regulation of CRAC channel ion selectivity by STIM1
por: McNally, Beth A., et al.
Publicado: (2012)

The basic residues in the Orai1 channel inner pore promote opening of the outer hydrophobic gate
por: Yamashita, Megumi, et al.
Publicado: (2019)

A sulfur-aromatic gate latch is essential for opening of the Orai1 channel pore
por: Yeung, Priscilla S-W, et al.
Publicado: (2020)

Orai1 Mutations Alter Ion Permeation and Ca(2+)-dependent Fast Inactivation of CRAC Channels: Evidence for Coupling of Permeation and Gating
por: Yamashita, Megumi, et al.
Publicado: (2007)

Mapping interactions between the CRAC activation domain and CC1 regulating the activity of the ER Ca(2+) sensor STIM1
por: Shrestha, Nisha, et al.
Publicado: (2022)

A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels
por: Yeung, Priscilla S-W, et al.
Publicado: (2023)

Regulation of CRAC Channel Activity by Recruitment of Silent Channels to a High Open-probability Gating Mode
por: Prakriya, Murali, et al.
Publicado: (2006)

Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 Binding
por: Tirado-Lee, Leidamarie, et al.
Publicado: (2015)

A severe defect in CRAC Ca(2+) channel activation and altered K(+) channel gating in T cells from immunodeficient patients
por: Feske, Stefan, et al.
Publicado: (2005)

Hydrophobic gasket mutation produces gating pore currents in closed human voltage-gated proton channels
por: Banh, Richard, et al.
Publicado: (2019)

Separation and Characterization of Currents through Store-operated CRAC Channels and Mg(2+)-inhibited Cation (MIC) Channels
por: Prakriya, Murali, et al.
Publicado: (2002)

Physiological CRAC channel activation and pore properties require STIM1 binding to all six Orai1 subunits
por: Yen, Michelle, et al.
Publicado: (2018)

A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels
por: Zheng, Wang, et al.
Publicado: (2019)

Structural Basis for Gating Pore Current in Periodic Paralysis
por: Jiang, Daohua, et al.
Publicado: (2018)

Essential Role for the CRAC Activation Domain in Store-dependent Oligomerization of STIM1
por: Covington, Elizabeth D., et al.
Publicado: (2010)

S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activation
por: Yu, Tao, et al.
Publicado: (2023)

Hydrophobic Gating of Ion Permeation in Magnesium Channel CorA
por: Neale, Chris, et al.
Publicado: (2015)

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers
por: Penna, Aubin, et al.
Publicado: (2008)

Regulation of Orai1/STIM1 mediated I(CRAC) by intracellular pH
por: Gavriliouk, D., et al.
Publicado: (2017)

Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1
por: Maltan, Lena, et al.
Publicado: (2023)

Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N terminus
por: Derler, Isabella, et al.
Publicado: (2018)

Interhelical interactions within the STIM1 CC1 domain modulate CRAC channel activation
por: Rathner, Petr, et al.
Publicado: (2021)

STIM1-mediated bidirectional regulation of Ca(2+) entry through voltage-gated calcium channels (VGCC) and calcium-release activated channels (CRAC)
por: Harraz, Osama F., et al.
Publicado: (2014)

Divergence of Ca(2+) selectivity and equilibrium Ca(2+) blockade in a Ca(2+) release-activated Ca(2+) channel
por: Yamashita, Megumi, et al.
Publicado: (2014)

STIM1 activation is regulated by a 14 amino acid sequence adjacent to the CRAC activation domain
por: Korzeniowski, Marek K., et al.
Publicado: (2016)

The action of selective CRAC channel blockers is affected by the Orai pore geometry
por: Derler, Isabella, et al.
Publicado: (2013)

Defects in the STIM1 SOARα2 domain affect multiple steps in the CRAC channel activation cascade
por: Höglinger, Carmen, et al.
Publicado: (2021)

Unveiling the Gating Mechanism of CRAC Channel: A Computational Study
por: Guardiani, Carlo, et al.
Publicado: (2021)

The exquisitely cooperative nature of Orai1 channel activation
por: Yeung, Priscilla See-Wai, et al.
Publicado: (2018)

Orai1 pore residues control CRAC channel inactivation independently of calmodulin
por: Mullins, Franklin M., et al.
Publicado: (2016)

The Hydrophobic Effect Contributes to the Closed State of a Simplified Ion Channel through a Conserved Hydrophobic Patch at the Pore-Helix Crossing
por: Yonkunas, Michael, et al.
Publicado: (2015)

¿Cric? ¡Crac! /
por: Danticat, Edwidge, 1969-
Publicado: (1999)

Correction: Orai1 pore residues control CRAC channel inactivation independently of calmodulin
por: Mullins, Franklin M., et al.
Publicado: (2016)

The elementary unit of store-operated Ca(2+) entry: local activation of CRAC channels by STIM1 at ER–plasma membrane junctions
por: Luik, Riina M., et al.
Publicado: (2006)

TRESK background potassium channel is not gated at the helix bundle crossing near the cytoplasmic end of the pore
por: Lengyel, Miklós, et al.
Publicado: (2018)

Interactions between selectivity filter and pore helix control filter gating in the MthK channel
por: Kopec, Wojciech, et al.
Publicado: (2023)

When is a hydrophobic gate not a hydrophobic gate?
por: Seiferth, David, et al.
Publicado: (2022)

2-Aminoethoxydiphenyl Borate Potentiates CRAC Current by Directly Dilating the Pore of Open Orai1
por: Xu, Xiaolan, et al.
Publicado: (2016)

Breaking the Hydrophobicity of the MscL Pore: Insights into a Charge-Induced Gating Mechanism
por: Chandramouli, Balasubramanian, et al.
Publicado: (2015)

The Inhibitory Helix Controls the Intramolecular Conformational Switching of the C-Terminus of STIM1
por: Cui, Boyang, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_m1ldejkm58svs4f15p14jol85r