Population Pharmacokinetics Modeling of Unbound Efavirenz, Atazanavir, and Ritonavir in HIV‐Infected Subjects With Aging Biomarkers

Unbound drug is the pharmacodynamically relevant concentration. This study aimed to determine if chronologic age or markers of biologic aging, such as the frailty phenotype and p16(INK4a) gene expression, altered unbound pharmacokinetics (PKs) of efavirenz (EFV) and atazanavir/ritonavir (ATV/RTV). S...

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Detalles Bibliográficos
Autores principales: Dumond, JB, Chen, J, Cottrell, M, Trezza, CR, Prince, HMA, Sykes, C, Torrice, C, White, N, Malone, S, Wang, R, Patterson, KB, Sharpless, NE, Forrest, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321807/
https://www.ncbi.nlm.nih.gov/pubmed/28032946
http://dx.doi.org/10.1002/psp4.12151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321807/
https://www.ncbi.nlm.nih.gov/pubmed/28032946
http://dx.doi.org/10.1002/psp4.12151

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