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MYPT1 isoforms expressed in HEK293T cells are differentially phosphorylated after GTPγS treatment

Agonist stimulation of smooth muscle is known to activate RhoA/Rho kinase signaling, and Rho kinase phosphorylates the myosin targeting subunit (MYPT1) of myosin light chain (MLC) phosphatase at Thr696 and Thr853, which inhibits the activity of MLC phosphatase to produce a Ca(2+) independent increas...

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Detalles Bibliográficos
Autores principales: Lin, Simon, Brozovich, Frank V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Society of Smooth Muscle Research 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321854/
https://www.ncbi.nlm.nih.gov/pubmed/27725371
http://dx.doi.org/10.1540/jsmr.52.66