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MYPT1 isoforms expressed in HEK293T cells are differentially phosphorylated after GTPγS treatment
Agonist stimulation of smooth muscle is known to activate RhoA/Rho kinase signaling, and Rho kinase phosphorylates the myosin targeting subunit (MYPT1) of myosin light chain (MLC) phosphatase at Thr696 and Thr853, which inhibits the activity of MLC phosphatase to produce a Ca(2+) independent increas...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Japan Society of Smooth Muscle Research
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321854/ https://www.ncbi.nlm.nih.gov/pubmed/27725371 http://dx.doi.org/10.1540/jsmr.52.66 |