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α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson’s disease patients

Parkinson’s disease (PD) is characterized by the presence of inclusions known as Lewy bodies, which mainly consist of α-synuclein (α-syn) aggregates. There is growing evidence that α-syn self-propagates in non-neuronal cells, thereby contributing to the progression and spread of PD pathology in the...

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Detalles Bibliográficos
Autores principales: Dieriks, Birger Victor, Park, Thomas I-H., Fourie, Chantelle, Faull, Richard L. M., Dragunow, Mike, Curtis, Maurice A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322400/
https://www.ncbi.nlm.nih.gov/pubmed/28230073
http://dx.doi.org/10.1038/srep42984