Cargando…

MiRNA-21 mediates the antiangiogenic activity of metformin through targeting PTEN and SMAD7 expression and PI3K/AKT pathway

Metformin, an anti-diabetic drug commonly used for type 2 diabetes therapy, is associated with anti-angiogenic effects in conditions beyond diabetes. miR-21 has been reported to be involved in the process of angiogenesis. However, the precise regulatory mechanisms by which the metformin-induced endo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Mao, Tan, Xiaoyong, Mu, Lin, Luo, Yulin, Li, Rong, Deng, Xin, Chen, Ni, Ren, Meiping, Li, Yongjie, Wang, Liqun, Wu, Jianbo, Wan, Qin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322530/ https://www.ncbi.nlm.nih.gov/pubmed/28230206 http://dx.doi.org/10.1038/srep43427

Ejemplares similares

MiRNA-132 regulates the development of osteoarthritis in correlation with the modulation of PTEN/PI3K/AKT signaling
por: Zhang, Wei, et al.
Publicado: (2021)

靶向抑制miRNA-21对K562细胞增殖及PTEN-PI3K/AKT通路的影响
Publicado: (2016)

Circulating exosomal miR-21 mediates HUVEC proliferation and migration through PTEN/PI3K/AKT in Crohn’s disease
por: Xie, Xiaoran, et al.
Publicado: (2022)

miRNA-21 promotes osteogenesis via the PTEN/PI3K/Akt/HIF-1α pathway and enhances bone regeneration in critical size defects
por: Yang, Chi, et al.
Publicado: (2019)

miRNA-186 Improves Sepsis Induced Renal Injury Via PTEN/PI3K/AKT/P53 Pathway
por: Li, Min, et al.
Publicado: (2020)

PRL-3 promotes the peritoneal metastasis of gastric cancer through the PI3K/Akt signaling pathway by regulating PTEN
por: Xiong, Jianbo, et al.
Publicado: (2016)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

Angiopoietin-2 impairs collateral artery growth associated with the suppression of the infiltration of macrophages in mouse hindlimb ischaemia
por: Tan, Xiaoyong, et al.
Publicado: (2016)

Ischemic Postconditioning-Mediated miRNA-21 Protects against Cardiac ischemia/reperfusion Injury via PTEN/Akt Pathway
por: Tu, Yingfeng, et al.
Publicado: (2013)

PTEN regulation of the proliferation and differentiation of auditory progenitors through the PTEN/PI3K/Akt-signaling pathway in mice
por: Sun, Chen, et al.
Publicado: (2014)

MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer
por: Zheng, Lin, et al.
Publicado: (2015)

Tetrandrine inhibits proliferation of colon cancer cells by BMP9/ PTEN/ PI3K/AKT signaling
por: Zhou, Ya, et al.
Publicado: (2019)

miR-19b-3p relieves intervertebral disc degeneration through modulating PTEN/PI3K/Akt/mTOR signaling pathway
por: Zhao, Yulin, et al.
Publicado: (2021)

MiR-21 promotes pterygium cell proliferation through the PTEN/AKT pathway
por: Li, Xia, et al.
Publicado: (2018)

Formononetin induces vasorelaxation in rat thoracic aorta via regulation of the PI3K/PTEN/Akt signaling pathway
por: Li, Teng, et al.
Publicado: (2018)

miRNA-425-5p enhances lung cancer growth via the PTEN/PI3K/AKT signaling axis
por: Zhou, Jin-shan, et al.
Publicado: (2020)

miR-21 antagonist alleviates colitis and angiogenesis via the PTEN/PI3K/AKT pathway in colitis mice induced by TNBS
por: Xie, Xiaoran, et al.
Publicado: (2022)

Ursolic Acid Attenuates Diabetic Mesangial Cell Injury through the Up-Regulation of Autophagy via miRNA-21/PTEN/Akt/mTOR Suppression
por: Lu, Xinxing, et al.
Publicado: (2015)

Effects of miR-21 on proliferation and apoptosis of WT cells via PTEN/Akt pathway
por: Zhang, Xiuli, et al.
Publicado: (2020)

The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models
por: Carnero, Amancio, et al.
Publicado: (2014)

Dysregulation of PI3K/Akt/PTEN Pathway in Canine Mammary Tumor
por: Kim, Soo-Hyeon, et al.
Publicado: (2021)

Matrix Stiffness-Upregulated MicroRNA-17-5p Attenuates the Intervention Effects of Metformin on HCC Invasion and Metastasis by Targeting the PTEN/PI3K/Akt Pathway
por: Gao, Xiangyu, et al.
Publicado: (2020)

TGF-β induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer
por: Singha, Prajjal K., et al.
Publicado: (2014)

miR-21 increases c-kit(+) cardiac stem cell proliferation in vitro through PTEN/PI3K/Akt signaling
por: Shi, Bei, et al.
Publicado: (2017)

miR-21 promotes osteoclastogenesis through activation of PI3K/Akt signaling by targeting Pten in RAW264.7 cells
por: Wang, Shengli, et al.
Publicado: (2020)

Signal peptidase 21 suppresses cell proliferation, migration, and invasion via the PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma
por: Zhang, Na, et al.
Publicado: (2022)

PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis
por: Okumura, Naoko, et al.
Publicado: (2012)

Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy
por: Matsuda, Satoru, et al.
Publicado: (2013)

PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis
por: Lee, Min-Sik, et al.
Publicado: (2015)

Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma
por: Kessler, Tobias, et al.
Publicado: (2015)

The PI3K/AKT Pathway and PTEN Gene Are Involved in “Tree-Top Disease” of Lymantria dispar
por: Li, Fengjiao, et al.
Publicado: (2022)

Hyperglycaemia-induced reciprocal changes in miR-30c and PAI-1 expression in platelets
por: Luo, Mao, et al.
Publicado: (2016)

Knockdown of CENPK inhibits cell growth and facilitates apoptosis via PTEN‐PI3K‐AKT signalling pathway in gastric cancer
por: Wu, Shusheng, et al.
Publicado: (2021)

Additive Antiproliferative and Antiangiogenic Effects of Metformin and Pemetrexed in a Non-Small-Cell Lung Cancer Xenograft Model
por: Wang, Jiun-Long, et al.
Publicado: (2021)

Long Non-Coding RNA 691 Regulated PTEN/PI3K/AKT Signaling Pathway in Osteosarcoma Through miRNA-9-5p
por: Yao, Pengju, et al.
Publicado: (2020)

lncNALT knockdown ameliorates hypertensive retinopathy via PTEN/PI3K/AKT pathway
por: Kang, Haijun, et al.
Publicado: (2023)

LINC00511 promotes gastric cancer progression by regulating SOX4 and epigenetically repressing PTEN to activate PI3K/AKT pathway
por: Wang, Qianwei, et al.
Publicado: (2021)

Coculture of cancer cells with platelets increases their survival and metastasis by activating the TGFβ/Smad/PAI-1 and PI3K/AKT pathways
por: Tong, Haibo, et al.
Publicado: (2023)

Polydatin Prevents Methylglyoxal-Induced Apoptosis through Reducing Oxidative Stress and Improving Mitochondrial Function in Human Umbilical Vein Endothelial Cells
por: Pang, Ningbo, et al.
Publicado: (2017)

The Down-Regulation of lncRNA PCAT18 Promotes the Progression of Gastric Cancer via MiR-107/PTEN/PI3K/AKT Signaling Pathway
por: Chen, Ping, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_iqvevgobc8e0evvqqtnvhoifg4