Suppression of TGF-β pathway by pirfenidone decreases extracellular matrix deposition in ocular fibroblasts in vitro

In glaucoma surgery, fibrotic processes occur, leading to impairment of liquid outflow. Activated fibroblasts are responsible for postoperative scarring. The transforming growth factor-β (TGF-β) pathway plays a key role in fibroblast function, differentiation and proliferation. The aim of this study...

Descripción completa

Detalles Bibliográficos
Autores principales: Stahnke, Thomas, Kowtharapu, Bhavani S., Stachs, Oliver, Schmitz, Klaus-Peter, Wurm, Johannes, Wree, Andreas, Guthoff, Rudolf Friedrich, Hovakimyan, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322922/
https://www.ncbi.nlm.nih.gov/pubmed/28231275
http://dx.doi.org/10.1371/journal.pone.0172592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322922/
https://www.ncbi.nlm.nih.gov/pubmed/28231275
http://dx.doi.org/10.1371/journal.pone.0172592

Ejemplares similares