Cargando…

Suppression of TGF-β pathway by pirfenidone decreases extracellular matrix deposition in ocular fibroblasts in vitro

In glaucoma surgery, fibrotic processes occur, leading to impairment of liquid outflow. Activated fibroblasts are responsible for postoperative scarring. The transforming growth factor-β (TGF-β) pathway plays a key role in fibroblast function, differentiation and proliferation. The aim of this study...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stahnke, Thomas, Kowtharapu, Bhavani S., Stachs, Oliver, Schmitz, Klaus-Peter, Wurm, Johannes, Wree, Andreas, Guthoff, Rudolf Friedrich, Hovakimyan, Marina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322922/ https://www.ncbi.nlm.nih.gov/pubmed/28231275 http://dx.doi.org/10.1371/journal.pone.0172592

Ejemplares similares

Role of Bone Morphogenetic Protein 7 (BMP7) in the Modulation of Corneal Stromal and Epithelial Cell Functions
por: Kowtharapu, Bhavani S., et al.
Publicado: (2018)

Suppression of the TGF-β pathway by a macrolide antibiotic decreases fibrotic responses by ocular fibroblasts in vitro
por: Stahnke, Thomas, et al.
Publicado: (2020)

Ocular fibroblast types differ in their mRNA profiles—implications for fibrosis prevention after aqueous shunt implantation
por: Löbler, Marian, et al.
Publicado: (2013)

Collagen Cross-Linking: Current Status and Future Directions
por: Hovakimyan, Marine, et al.
Publicado: (2012)

Corneal Alterations during Combined Therapy with Cyclodextrin/Allopregnanolone and Miglustat in a Knock-Out Mouse Model of NPC1 Disease
por: Hovakimyan, Marine, et al.
Publicado: (2011)

Role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing
por: Kowtharapu, Bhavani S., et al.
Publicado: (2018)

Effect of Pirfenidone on TGF-β1-Induced Myofibroblast Differentiation and Extracellular Matrix Homeostasis of Human Orbital Fibroblasts in Graves’ Ophthalmopathy
por: Wu, Shi-Bei, et al.
Publicado: (2021)

Micro-CT in ophthalmology: ex vivo preparation and contrasting methods for detailed 3D-visualization of eye anatomy with special emphasis on critical point drying
por: Runge, Jens, et al.
Publicado: (2022)

The Antibiotic Kitasamycin—A Potential Agent for Specific Fibrosis Preventing Therapy after Fistulating Glaucoma Surgery?
por: Sterenczak, Katharina A., et al.
Publicado: (2023)

Analysis of the Differential Gene and Protein Expression Profiles of Corneal Epithelial Cells Stimulated with Alternating Current Electric Fields
por: Kowtharapu, Bhavani S., et al.
Publicado: (2021)

Development of a biodegradable antifibrotic local drug delivery system for glaucoma microstents
por: Stahnke, Thomas, et al.
Publicado: (2018)

Ophthalmic Ultrasonography in Sub-Saharan Africa—A Kinshasa Experience
por: Ngweme, Georgette, et al.
Publicado: (2021)

Changes in the micromorphology of the corneal subbasal nerve plexus in patients after plaque brachytherapy
por: Zhivov, Andrey, et al.
Publicado: (2013)

Morphologic and biometric evaluation of chick embryo eyes in ovo using 7 Tesla MRI
por: Lindner, Tobias, et al.
Publicado: (2017)

MR microscopy of the human fetal upper extremity – a proof-of-principle study
por: Langner, Inga, et al.
Publicado: (2016)

Investigating the effects of Pirfenidone on TGF-β1 stimulated non-SMAD signaling pathways in Dupuytren’s disease -derived fibroblasts
por: Zhou, Chaoming, et al.
Publicado: (2019)

The in vitro anti-fibrotic effect of Pirfenidone on human pterygium fibroblasts is associated with down-regulation of autocrine TGF-β and MMP-1
por: Tao, Yijin, et al.
Publicado: (2020)

Inhibition of TGF-β2–Induced Trabecular Meshwork Fibrosis by Pirfenidone
por: Zhu, Xiaofeng, et al.
Publicado: (2023)

Age-Related Changes of the Human Crystalline Lens on High-Spatial Resolution Three-Dimensional T1-Weighted Brain Magnetic Resonance Images In Vivo
por: Streckenbach, Felix, et al.
Publicado: (2020)

Anti-fibrotic action of pirfenidone in Dupuytren’s disease-derived fibroblasts
por: Zhou, Chaoming, et al.
Publicado: (2016)

Effects of Pirfenidone and Collagen-Polyvinylpyrrolidone on Macroscopic and Microscopic Changes, TGF-β1 Expression, and Collagen Deposition in an Experimental Model of Tracheal Wound Healing
por: Olmos-Zuñiga, J. Raúl, et al.
Publicado: (2017)

Pirfenidone and nintedanib modulate properties of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis
por: Lehtonen, Siri T., et al.
Publicado: (2016)

Defects in the retina of Niemann-pick type C 1 mutant mice
por: Yan, Xin, et al.
Publicado: (2014)

Imaging and Quantification of Subbasal Nerve Plexus in Healthy Volunteers and Diabetic Patients with or without Retinopathy
por: Zhivov, Andrey, et al.
Publicado: (2013)

Platelet-Derived PDGFB Promotes Recruitment of Cancer-Associated Fibroblasts, Deposition of Extracellular Matrix and Tgfβ Signaling in the Tumor Microenvironment
por: Zhang, Yanyu, et al.
Publicado: (2022)

Pirfenidone Alleviates Choroidal Neovascular Fibrosis through TGF-β/Smad Signaling Pathway
por: Gao, Chuang, et al.
Publicado: (2021)

Pirfenidone: is it tolerable?
por: Lara, Abigail, et al.
Publicado: (2016)

The antifibrotic drug pirfenidone inhibits spondyloarthritis fibroblast-like synoviocytes and osteoblasts in vitro
por: Stougaard, Julie, et al.
Publicado: (2018)

Non-invasive detection of corneal sub-basal nerve plexus changes in multiple myeloma patients by confocal laser scanning microscopy
por: Koschmieder, Anita, et al.
Publicado: (2020)

Atypical Cellular Elements of Unknown Origin in the Subbasal Nerve Plexus of a Diabetic Cornea Diagnosed by Large-Area Confocal Laser Scanning Microscopy
por: Sterenczak, Katharina A., et al.
Publicado: (2021)

Multiple Fibroblast Subtypes Contribute to Matrix Deposition in Pulmonary Fibrosis
por: Liu, Xue, et al.
Publicado: (2023)

In Vitro Effects of Pirfenidone on Cardiac Fibroblasts: Proliferation, Myofibroblast Differentiation, Migration and Cytokine Secretion
por: Shi, Qiang, et al.
Publicado: (2011)

Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1
por: Jin, Jin, et al.
Publicado: (2019)

Pirfenidone Inhibits Cell Proliferation and Collagen I Production of Primary Human Intestinal Fibroblasts
por: Cui, Yingying, et al.
Publicado: (2020)

Mesoporous Polydopamine Loaded Pirfenidone Target to Fibroblast Activation Protein for Pulmonary Fibrosis Therapy
por: Fang, Qi, et al.
Publicado: (2022)

Prevalence and patterns of childhood ocular morbidity in Kinshasa. A population-based study
por: Nsiangani Lusambo, Nadine, et al.
Publicado: (2021)

E2F1 confers anticancer drug resistance by targeting ABC transporter family members and Bcl-2 via the p73/DNp73-miR-205 circuitry
por: Alla, Vijay, et al.
Publicado: (2012)

Pirfenidone suppressed triple‐negative breast cancer metastasis by inhibiting the activity of the TGF‐β/SMAD pathway
por: Luo, Daiqin, et al.
Publicado: (2023)

Role of a Community-based Program for Identification and Referral of Pediatric Cataract Patients in Kinshasa, Democratic Republic of the Congo
por: Kilangalanga, Janvier Ngoy, et al.
Publicado: (2019)

The anti-fibrotic agent pirfenidone synergizes with cisplatin in killing tumor cells and cancer-associated fibroblasts
por: Mediavilla-Varela, Melanie, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_9l2tktdndhqvqfvurlpirkcjs1