Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory

SNX6 is a ubiquitously expressed PX-BAR protein that plays important roles in retromer-mediated retrograde vesicular transport from endosomes. Here we report that CNS-specific Snx6 knockout mice exhibit deficits in spatial learning and memory, accompanied with loss of spines from distal dendrites of...

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Detalles Bibliográficos
Autores principales: Niu, Yang, Dai, Zhonghua, Liu, Wenxue, Zhang, Cheng, Yang, Yanrui, Guo, Zhenzhen, Li, Xiaoyu, Xu, Chenchang, Huang, Xiahe, Wang, Yingchun, Shi, Yun S, Liu, Jia-Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323044/
https://www.ncbi.nlm.nih.gov/pubmed/28134614
http://dx.doi.org/10.7554/eLife.20991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323044/
https://www.ncbi.nlm.nih.gov/pubmed/28134614
http://dx.doi.org/10.7554/eLife.20991

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