Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

Autophagy is an intracellular recycling and degradation pathway that depends on membrane trafficking. Rab GTPases are central for autophagy but their regulation especially through the activity of Rab GEFs remains largely elusive. We employed a RNAi screen simultaneously monitoring different populati...

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Detalles Bibliográficos
Autores principales: Jung, Jennifer, Nayak, Arnab, Schaeffer, Véronique, Starzetz, Tatjana, Kirsch, Achim K, Müller, Stefan, Dikic, Ivan, Mittelbronn, Michel, Behrends, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323046/
https://www.ncbi.nlm.nih.gov/pubmed/28195531
http://dx.doi.org/10.7554/eLife.23063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323046/
https://www.ncbi.nlm.nih.gov/pubmed/28195531
http://dx.doi.org/10.7554/eLife.23063

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