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RALB provides critical survival signals downstream of Ras in acute myeloid leukemia
Mutations that activate RAS proto-oncogenes and their effectors are common in acute myeloid leukemia (AML); however, efforts to therapeutically target Ras or its effectors have been unsuccessful, and have been hampered by an incomplete understanding of which effectors are required for AML proliferat...
Autores principales: | Eckfeldt, Craig E., Pomeroy, Emily J., Lee, Robin D.W., Hazen, Katherine S., Lee, Lindsey A., Moriarity, Branden S., Largaespada, David A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323144/ https://www.ncbi.nlm.nih.gov/pubmed/27556501 http://dx.doi.org/10.18632/oncotarget.11431 |
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