Co-inhibition of pol θ and HR genes efficiently synergize with cisplatin to suppress cisplatin-resistant lung cancer cells survival

Cisplatin exert its anticancer effect by creating intrastrand and interstrand DNA cross-links which block DNA replication and is a major drug used to treat lung cancer. However, the main obstacle of the efficacy of treatment is drug resistance. Here, we show that expression of translesion synthesis...

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Detalles Bibliográficos
Autores principales: Dai, Chun-Hua, Chen, Ping, Li, Jian, Lan, Tin, Chen, Yong-Chang, Qian, Hai, Chen, Kang, Li, Mei-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323145/
https://www.ncbi.nlm.nih.gov/pubmed/27533083
http://dx.doi.org/10.18632/oncotarget.11214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323145/
https://www.ncbi.nlm.nih.gov/pubmed/27533083
http://dx.doi.org/10.18632/oncotarget.11214

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