A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer’s mouse model via an HSF1-mediated mechanism

Induction of neuroprotective heat-shock proteins via pharmacological Hsp90 inhibitors is currently being investigated as a potential treatment for neurodegenerative diseases. Two major hurdles for therapeutic use of Hsp90 inhibitors are systemic toxicity and limited CNS permeability. We demonstrate...

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Detalles Bibliográficos
Autores principales: Wang, Bin, Liu, Yu, Huang, Lianyan, Chen, Jianjun, Li, Jing jing, Wang, Ruishan, Kim, Eunhee, Justicia, Carles, Sakata, Kazuko, Chen, Hao, Planas, Anna, Ostrom, Rennolds S, Li, Wei, Yang, Guang, McDonald, Michael P., Chen, Ruihong, Heck, Detlef, Liao, Francesca-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323357/
https://www.ncbi.nlm.nih.gov/pubmed/27457810
http://dx.doi.org/10.1038/mp.2016.104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323357/
https://www.ncbi.nlm.nih.gov/pubmed/27457810
http://dx.doi.org/10.1038/mp.2016.104

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