MDA5 Induces a Stronger Interferon Response than RIG-I to GCRV Infection through a Mechanism Involving the Phosphorylation and Dimerization of IRF3 and IRF7 in CIK Cells

Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) are critical cytosolic sensors that trigger the production of interferons (IFNs). Though their recognition functions are well identified, their unique roles in the downstream signal transduction remain to be...

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Detalles Bibliográficos
Autores principales: Wan, Quanyuan, Yang, Chunrong, Rao, Youliang, Liao, Zhiwei, Su, Jianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323377/
https://www.ncbi.nlm.nih.gov/pubmed/28286505
http://dx.doi.org/10.3389/fimmu.2017.00189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323377/
https://www.ncbi.nlm.nih.gov/pubmed/28286505
http://dx.doi.org/10.3389/fimmu.2017.00189

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