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Reduction of dopamine D(2/3) receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys

R-ketamine appears to be a potent, long-lasting and safer antidepressant, relative to esketamine (S-ketamine), since it might be free of psychotomimetic side effects. Using [(11)C]raclopride and positron emission tomography (PET), we investigated whether esketamine and R-ketamine can affect dopamine...

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Autores principales: Hashimoto, Kenji, Kakiuchi, Takeharu, Ohba, Hiroyuki, Nishiyama, Shingo, Tsukada, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323469/
https://www.ncbi.nlm.nih.gov/pubmed/27091456
http://dx.doi.org/10.1007/s00406-016-0692-7
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author Hashimoto, Kenji
Kakiuchi, Takeharu
Ohba, Hiroyuki
Nishiyama, Shingo
Tsukada, Hideo
author_facet Hashimoto, Kenji
Kakiuchi, Takeharu
Ohba, Hiroyuki
Nishiyama, Shingo
Tsukada, Hideo
author_sort Hashimoto, Kenji
collection PubMed
description R-ketamine appears to be a potent, long-lasting and safer antidepressant, relative to esketamine (S-ketamine), since it might be free of psychotomimetic side effects. Using [(11)C]raclopride and positron emission tomography (PET), we investigated whether esketamine and R-ketamine can affect dopamine D(2/3) receptor binding in the conscious monkey brain. A single infusion of esketamine (0.5 mg/kg), but not R-ketamine (0.5 mg/kg), caused a reduction of binding availability of dopamine D(2/3) receptor in the monkey striatum. This study suggests that unlike to R-ketamine, esketamine can cause dopamine release in the striatum, and that its release might be associated with psychotomimetic effects of esketamine.
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spelling pubmed-53234692017-03-09 Reduction of dopamine D(2/3) receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys Hashimoto, Kenji Kakiuchi, Takeharu Ohba, Hiroyuki Nishiyama, Shingo Tsukada, Hideo Eur Arch Psychiatry Clin Neurosci Short Communication R-ketamine appears to be a potent, long-lasting and safer antidepressant, relative to esketamine (S-ketamine), since it might be free of psychotomimetic side effects. Using [(11)C]raclopride and positron emission tomography (PET), we investigated whether esketamine and R-ketamine can affect dopamine D(2/3) receptor binding in the conscious monkey brain. A single infusion of esketamine (0.5 mg/kg), but not R-ketamine (0.5 mg/kg), caused a reduction of binding availability of dopamine D(2/3) receptor in the monkey striatum. This study suggests that unlike to R-ketamine, esketamine can cause dopamine release in the striatum, and that its release might be associated with psychotomimetic effects of esketamine. Springer Berlin Heidelberg 2016-04-18 2017 /pmc/articles/PMC5323469/ /pubmed/27091456 http://dx.doi.org/10.1007/s00406-016-0692-7 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Short Communication
Hashimoto, Kenji
Kakiuchi, Takeharu
Ohba, Hiroyuki
Nishiyama, Shingo
Tsukada, Hideo
Reduction of dopamine D(2/3) receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys
title Reduction of dopamine D(2/3) receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys
title_full Reduction of dopamine D(2/3) receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys
title_fullStr Reduction of dopamine D(2/3) receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys
title_full_unstemmed Reduction of dopamine D(2/3) receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys
title_short Reduction of dopamine D(2/3) receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys
title_sort reduction of dopamine d(2/3) receptor binding in the striatum after a single administration of esketamine, but not r-ketamine: a pet study in conscious monkeys
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323469/
https://www.ncbi.nlm.nih.gov/pubmed/27091456
http://dx.doi.org/10.1007/s00406-016-0692-7
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