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Ubiquitin-specific peptidase 48 regulates Mdm2 protein levels independent of its deubiquitinase activity
The overexpression of Mdm2 has been linked to the loss of p53 tumour suppressor activity in several human cancers. Here, we present results suggesting that ubiquitin-specific peptidase 48 (USP48), a deubiquitinase that has been linked in previous reports to the NF-κB signaling pathway, is a novel Md...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324091/ https://www.ncbi.nlm.nih.gov/pubmed/28233861 http://dx.doi.org/10.1038/srep43180 |