Segmented linear modeling of CHO fed‐batch culture and its application to large scale production

We describe a systematic approach to model CHO metabolism during biopharmaceutical production across a wide range of cell culture conditions. To this end, we applied the metabolic steady state concept. We analyzed and modeled the production rates of metabolites as a function of the specific growth r...

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Detalles Bibliográficos
Autores principales: Ben Yahia, Bassem, Gourevitch, Boris, Malphettes, Laetitia, Heinzle, Elmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324675/
https://www.ncbi.nlm.nih.gov/pubmed/27869296
http://dx.doi.org/10.1002/bit.26214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324675/
https://www.ncbi.nlm.nih.gov/pubmed/27869296
http://dx.doi.org/10.1002/bit.26214

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