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Segmented linear modeling of CHO fed‐batch culture and its application to large scale production

We describe a systematic approach to model CHO metabolism during biopharmaceutical production across a wide range of cell culture conditions. To this end, we applied the metabolic steady state concept. We analyzed and modeled the production rates of metabolites as a function of the specific growth r...

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Detalles Bibliográficos
Autores principales:	Ben Yahia, Bassem, Gourevitch, Boris, Malphettes, Laetitia, Heinzle, Elmar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324675/ https://www.ncbi.nlm.nih.gov/pubmed/27869296 http://dx.doi.org/10.1002/bit.26214

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