Biotransformation of a potent anabolic steroid, mibolerone, with Cunninghamella blakesleeana, C. echinulata, and Macrophomina phaseolina, and biological activity evaluation of its metabolites

Seven metabolites were obtained from the microbial transformation of anabolic-androgenic steroid mibolerone (1) with Cunninghamella blakesleeana, C. echinulata, and Macrophomina phaseolina. Their structures were determined as 10β,17β-dihydroxy-7α,17α-dimethylestr-4-en-3-one (2), 6β,17β-dihydroxy-7α,...

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Detalles Bibliográficos
Autores principales: Siddiqui, Mahwish, Ahmad, Malik Shoaib, Wahab, Atia-tul-, Yousuf, Sammer, Fatima, Narjis, Naveed Shaikh, Nimra, Rahman, Atta-ur-, Choudhary, M. Iqbal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325191/
https://www.ncbi.nlm.nih.gov/pubmed/28234904
http://dx.doi.org/10.1371/journal.pone.0171476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325191/
https://www.ncbi.nlm.nih.gov/pubmed/28234904
http://dx.doi.org/10.1371/journal.pone.0171476

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