Cargando…

Proof-of-Concept Randomized Trial of the Monoclonal Antibody GSK249320 Versus Placebo in Stroke Patients

BACKGROUND AND PURPOSE—: One class of poststroke restorative therapy focuses on promoting axon outgrowth by blocking myelin-based inhibitory proteins such as myelin-associated glycoprotein. The purpose of the current study was to extend preclinical and clinical findings of GSK249320, a humanized mon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cramer, Steven C., Enney, Lori A., Russell, Colleen K., Simeoni, Monica, Thompson, Thomas R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2017
Materias:	Original Contributions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325241/ https://www.ncbi.nlm.nih.gov/pubmed/28228578 http://dx.doi.org/10.1161/STROKEAHA.116.014517

Ejemplares similares

Methods for an International Randomized Clinical Trial to Investigate the Effect of Gsk249320 on Motor Cortex Neurophysiology using Transcranial Magnetic Stimulation in Survivors of Stroke
por: Malcolm, Matt P., et al.
Publicado: (2014)

GSK249320, A Monoclonal Antibody Against the Axon Outgrowth Inhibition Molecule Myelin-Associated Glycoprotein, Improves Outcome of Rodents with Experimental Stroke
por: Cash, Diana, et al.
Publicado: (2016)

Use of shoulder pacemaker for treatment of functional shoulder instability: Proof of concept
por: Moroder, Philipp, et al.
Publicado: (2017)

Quantitative temporal diffusion spectroscopy as an early imaging biomarker of radiation therapeutic response in gliomas: A preclinical proof of concept
por: Jiang, Xiaoyu, et al.
Publicado: (2018)

The Grow It! app—longitudinal changes in adolescent well-being during the COVID-19 pandemic: a proof-of-concept study
por: Dietvorst, E., et al.
Publicado: (2022)

Effect of Miricorilant, a Selective Glucocorticoid Receptor Modulator, on Olanzapine-Associated Weight Gain in Healthy Subjects: A Proof-of-Concept Study
por: Hunt, Hazel J., et al.
Publicado: (2021)

Anti‐IL‐7 receptor α monoclonal antibody (GSK2618960) in healthy subjects – a randomized, double‐blind, placebo‐controlled study
por: Ellis, Joanne, et al.
Publicado: (2018)

Identification of Lymphatics within the Colonic Lamina Propria in Inflammation and Neoplasia Using the Monoclonal Antibody D2-40
por: Kenney, Barton C., et al.
Publicado: (2008)

Cerebrolysin and Recovery After Stroke (CARS): A Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial
por: Muresanu, Dafin F., et al.
Publicado: (2016)

Sustained Delivery of a Monoclonal Antibody against SARS-CoV-2 by Microencapsulated Cells: A Proof-of-Concept Study
por: Ashimova, Assem, et al.
Publicado: (2022)

4C3 Human Monoclonal Antibody: A Proof of Concept for Non-pathogenic Proteinase 3 Anti-neutrophil Cytoplasmic Antibodies in Granulomatosis With Polyangiitis
por: Granel, Jérôme, et al.
Publicado: (2020)

MIDAS (Modafinil in Debilitating Fatigue After Stroke): A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial
por: Bivard, Andrew, et al.
Publicado: (2017)

An open-label, randomized, placebo-controlled study on the effectiveness of a novel probiotics administration protocol (ProbiotiCKD) in patients with mild renal insufficiency (stage 3a of CKD)
por: Simeoni, Mariadelina, et al.
Publicado: (2018)

Fasinumab (REGN475), an antinerve growth factor monoclonal antibody, for the treatment of acute sciatic pain: results of a proof-of-concept study
por: Tiseo, Paul J, et al.
Publicado: (2014)

A New Alternative Tool to Analyse Glycosylation in Monoclonal Antibodies Based on Drop-Coating Deposition Raman imaging: A Proof of Concept
por: Hamla, Sabrina, et al.
Publicado: (2022)

First Administration of the Fc-Attenuated Anti-β Amyloid Antibody GSK933776 to Patients with Mild Alzheimer’s Disease: A Randomized, Placebo-Controlled Study
por: Andreasen, Niels, et al.
Publicado: (2015)

Mathematical artificial intelligence design of mutation-proof COVID-19 monoclonal antibodies
por: Chen, Jiahui, et al.
Publicado: (2022)

Phase IIa Proof-of-Concept Evaluation of the Antiviral Efficacy, Safety, Tolerability, and Pharmacokinetics of the Next-Generation Maturation Inhibitor GSK3640254( )
por: Spinner, Christoph D, et al.
Publicado: (2022)

CROSS-STIMULATION OF MONOCLONAL ANTIBODIES IN ANAMNESTIC RESPONSES
por: Cramer, Matthias, et al.
Publicado: (1973)

Computer Modeling of Anterior Circulation Stroke: Proof of Concept in Cerebrovascular Occlusion
por: Phan, Thanh G., et al.
Publicado: (2014)

Pretreatment metabotype as a predictor of response to sertraline or placebo in depressed outpatients: a proof of concept
por: Kaddurah-Daouk, R, et al.
Publicado: (2011)

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene Xin moderate Alzheimer’s disease
por: Cummings, Jeffrey L., et al.
Publicado: (2016)

B-vitamins and body composition: integrating observational and experimental evidence from the B-PROOF study
por: Oliai Araghi, Sadaf, et al.
Publicado: (2019)

Triple-Gene Therapy for Stroke: A Proof-of-Concept in Vivo Study in Rats
por: Sokolov, Mikhail E., et al.
Publicado: (2018)

Reversed Mirror Therapy (REMIT) after Stroke—A Proof-of-Concept Study
por: Tesio, Luigi, et al.
Publicado: (2023)

Design of a Bayesian adaptive phase 2 proof-of-concept trial for BAN2401, a putative disease-modifying monoclonal antibody for the treatment of Alzheimer's disease
por: Satlin, Andrew, et al.
Publicado: (2016)

Treatment with the anti-IgE monoclonal antibody omalizumab in women with asthma undergoing fertility treatment: a proof-of-concept study—The PRO-ART study protocol
por: Tidemandsen, Casper, et al.
Publicado: (2020)

Proof of Concept, Randomized, Placebo-Controlled Study of the Effect of Simvastatin on the Course of Age-Related Macular Degeneration
por: Guymer, Robyn H., et al.
Publicado: (2013)

A Phase 2 Proof‐of‐Concept, Randomized, Placebo‐Controlled Trial of CX‐8998 in Essential Tremor
por: Papapetropoulos, Spyros, et al.
Publicado: (2021)

Proof-of-concept and Randomized, Placebo-controlled Trials of an FcRn Inhibitor, Batoclimab, for Thyroid Eye Disease
por: Kahaly, George J, et al.
Publicado: (2023)

Safety, Feasibility, and Efficacy of Vagus Nerve Stimulation Paired With Upper-Limb Rehabilitation After Ischemic Stroke
por: Dawson, Jesse, et al.
Publicado: (2016)

The Versatile Transceiver Proof of Concept
por: Troska, J, et al.
Publicado: (2009)

Detection of Cardioembolic Sources With Nongated Cardiac Computed Tomography Angiography in Acute Stroke: Results From the ENCLOSE Study
por: Kauw, Frans, et al.
Publicado: (2023)

An Investigation of Levetiracetam in Alzheimer’s Disease (ILiAD): a double-blind, placebo-controlled, randomised crossover proof of concept study
por: Sen, Arjune, et al.
Publicado: (2021)

The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis
por: Alten, Rieke, et al.
Publicado: (2008)

DHA status influences effects of B-vitamin supplementation on cognitive ageing: a post-hoc analysis of the B-proof trial
por: van Soest, Annick P. M., et al.
Publicado: (2022)

Do we need a threshold conception of competence?
por: den Hartogh, Govert
Publicado: (2015)

On recovery: re-directing the concept by differentiation of its meanings
por: Friedman, Yael
Publicado: (2021)

Automatic Setting Procedure for Exoskeleton-Assisted Overground Gait: Proof of Concept on Stroke Population
por: Gandolla, Marta, et al.
Publicado: (2018)

Nonhematopoietic Variants of Erythropoietin in Ischemic Stroke: Need for Step-Wise Proof-of-Concept Studies
por: Hermann, Dirk M.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_t4sqbd740q77ldbm6jed4ldrdl