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The effect of epigenetic silencing and TP53 mutation on the expression of DLL4 in human cancer stem disorder

The Li-Fraumeni Syndrome (LFS), a genetically rare heterogeneous cancer syndrome, is characterized primarily by a germline p53 (TP53) gene mutation. We recently discovered a balanced reciprocal chromosomal translocation t(11;15)(q23;q15) in the non-cancerous skin fibroblasts of a bilateral breast ca...

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Detalles Bibliográficos
Autores principales: Yao, Zhixing, Sherif, Zaki A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325341/
https://www.ncbi.nlm.nih.gov/pubmed/27542210
http://dx.doi.org/10.18632/oncotarget.11316