Reversibility of glioma stem cells’ phenotypes explains their complex in vitro and in vivo behavior: Discovery of a novel neurosphere-specific enzyme, cGMP-dependent protein kinase 1, using the genomic landscape of human glioma stem cells as a discovery tool

Glioma cells grow in two phenotypic forms, as adherent monolayers and as free floating “neurospheres/tumorspheres”, using specific media supplements. Whether each phenotype is irreversible remains unknown. Herein we show that both states are reversible using patient derived glioblastoma cell culture...

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Detalles Bibliográficos
Autores principales: Wilson, Thomas J., Zamler, Daniel B., Doherty, Robert, Castro, Maria G., Lowenstein, Pedro R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325344/
https://www.ncbi.nlm.nih.gov/pubmed/27564115
http://dx.doi.org/10.18632/oncotarget.11589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325344/
https://www.ncbi.nlm.nih.gov/pubmed/27564115
http://dx.doi.org/10.18632/oncotarget.11589

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