Differential effects of histone deacetylase inhibitors on cellular drug transporters and their implications for using epigenetic modifiers in combination chemotherapy

HDAC inhibitors, DNA alkylators and nucleoside analogs are effective components of combination chemotherapy. To determine a possible mechanism of their synergism, we analyzed the effects of HDAC inhibitors on the expression of drug transporters which export DNA alkylators. Exposure of PEER lymphoma...

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Detalles Bibliográficos
Autores principales: Valdez, Benigno C., Li, Yang, Murray, David, Brammer, Jonathan E., Liu, Yan, Hosing, Chitra, Nieto, Yago, Champlin, Richard E., Andersson, Borje S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325407/
https://www.ncbi.nlm.nih.gov/pubmed/27564097
http://dx.doi.org/10.18632/oncotarget.11561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325407/
https://www.ncbi.nlm.nih.gov/pubmed/27564097
http://dx.doi.org/10.18632/oncotarget.11561

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