Canstatin inhibits hypoxia-induced apoptosis through activation of integrin/focal adhesion kinase/Akt signaling pathway in H9c2 cardiomyoblasts

A hypoxic stress which causes apoptosis of cardiomyocytes is the main problem in the ischemic heart disease. Canstatin, a non-collagenous fragment of type IV collagen α2 chain, is an endogenous anti-angiogenic factor. We have previously reported that canstatin has a cytoprotective effect on cardiomy...

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Detalles Bibliográficos
Autores principales: Kanazawa, Hiroki, Imoto, Keisuke, Okada, Muneyoshi, Yamawaki, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325616/
https://www.ncbi.nlm.nih.gov/pubmed/28235037
http://dx.doi.org/10.1371/journal.pone.0173051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325616/
https://www.ncbi.nlm.nih.gov/pubmed/28235037
http://dx.doi.org/10.1371/journal.pone.0173051

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