Cargando…

Understand spiciness: mechanism of TRPV1 channel activation by capsaicin

Capsaicin in chili peppers bestows the sensation of spiciness. Since the discovery of its receptor, transient receptor potential vanilloid 1 (TRPV1) ion channel, how capsaicin activates this channel has been under extensive investigation using a variety of experimental techniques including mutagenes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Fan, Zheng, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Higher Education Press 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326624/ https://www.ncbi.nlm.nih.gov/pubmed/28044278 http://dx.doi.org/10.1007/s13238-016-0353-7

Ejemplares similares

Structural mechanism underlying capsaicin binding and activation of TRPV1 ion channel
por: Yang, Fan, et al.
Publicado: (2015)

Dietary Capsaicin: A Spicy Way to Improve Cardio-Metabolic Health?
por: Szallasi, Arpad
Publicado: (2022)

Capsaicin and TRPV1 Channels in the Cardiovascular System: The Role of Inflammation
por: Munjuluri, Sreepadaarchana, et al.
Publicado: (2021)

Endocannabinoid activation of the TRPV1 ion channel is distinct from activation by capsaicin
por: Li, Yanxin, et al.
Publicado: (2021)

The capsaicin binding affinity of wildtype and mutant TRPV1 ion channels
por: Li, Shisheng, et al.
Publicado: (2023)

Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations
por: Cui, Yuanyuan, et al.
Publicado: (2012)

Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies
por: Szabados, Tamara, et al.
Publicado: (2020)

Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance
por: Abdel-Salam, Omar M.E., et al.
Publicado: (2023)

Integrating TRPV1 Receptor Function with Capsaicin Psychophysics
por: Smutzer, Gregory, et al.
Publicado: (2016)

Molecular mechanism of the tree shrew’s insensitivity to spiciness
por: Han, Yalan, et al.
Publicado: (2018)

Ca(2+)/Calmodulin Modulates TRPV1 Activation by Capsaicin
por: Rosenbaum, Tamara, et al.
Publicado: (2004)

Rational discovery of new capsaicin analogues as TRPV1 activators
por: Cáceres, Javier, et al.
Publicado: (2015)

A Luminescence-Based Human TRPV1 Assay System for Quantifying Pungency in Spicy Foods
por: Matsuyama, Minami, et al.
Publicado: (2021)

Capsaicin Interaction with TRPV1 Channels in a Lipid Bilayer: Molecular Dynamics Simulation
por: Hanson, Sonya M., et al.
Publicado: (2015)

A Potential Route of Capsaicin to Its Binding Site in the TRPV1 Ion Channel
por: Domene, Carmen, et al.
Publicado: (2022)

Capsaicin, the Spicy Ingredient of Chili Peppers: Effects on Gastrointestinal Tract and Composition of Gut Microbiota at Various Dosages
por: Xiang, Qunran, et al.
Publicado: (2022)

The red pepper’s spicy ingredient capsaicin activates AMPK in HepG2 cells through CaMKKβ
por: Bort, Alicia, et al.
Publicado: (2019)

Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1
por: Eberhardt, Mirjam J., et al.
Publicado: (2017)

Opening of capsaicin receptor TRPV1 is stabilized equally by its four subunits
por: Li, Shisheng, et al.
Publicado: (2023)

ThermoTRP Channels in Nociceptors: Taking a Lead from Capsaicin Receptor TRPV1
por: Mandadi, Sravan, et al.
Publicado: (2008)

Novel TRPV1 Channel Agonists With Faster and More Potent Analgesic Properties Than Capsaicin
por: Duarte, Yorley, et al.
Publicado: (2020)

Beyond Neuronal Heat Sensing: Diversity of TRPV1 Heat-Capsaicin Receptor-Channel Functions
por: Shuba, Yaroslav M.
Publicado: (2021)

The Spicy Story of Cannabimimetic Indoles
por: Howlett, Allyn C., et al.
Publicado: (2021)

Cost-Effective Pipeline for a Rational Design and Selection of Capsaicin Analogues Targeting TRPV1 Channels
por: Bustos, Daniel, et al.
Publicado: (2023)

Voltage-Dependent Interaction of Capsaicine and Protons on TRPV1-Receptors
por: Tsvetkov, E.A., et al.
Publicado: (2017)

Acidification of rat TRPV1 alters the kinetics of capsaicin responses
por: Neelands, Torben R, et al.
Publicado: (2005)

Lactate is a potent inhibitor of the capsaicin receptor TRPV1
por: de la Roche, Jeanne, et al.
Publicado: (2016)

Capsaicin Inhibits Multiple Voltage-Gated Ion Channels in Rabbit Ventricular Cardiomyocytes in TRPV1-Independent Manner
por: Isaev, Dmytro, et al.
Publicado: (2022)

TRPV1 Receptor-Mediated Hypoglycemic Mechanism of Capsaicin in Streptozotocin-Induced Diabetic Rats
por: Zhang, Shiqi, et al.
Publicado: (2021)

Changes in TRPV1-Mediated Physiological Function in Rats Systemically Treated With Capsaicin on the Neonate
por: Jeong, Keun-Yeong
Publicado: (2020)

An Unorthodox Mechanism Underlying Voltage Sensitivity of TRPV1 Ion Channel
por: Yang, Fan, et al.
Publicado: (2020)

Curcumin: the spicy modulator of breast carcinogenesis
por: Banik, Urmila, et al.
Publicado: (2017)

A proinflammatory chemokine, CCL3, sensitizes the heat-gated and capsaicin-gated ion channel, TRPV1
por: Zhang, N, et al.
Publicado: (2004)

Rice and Spicy Diet
por: Wiwanitkit, Viroj
Publicado: (2010)

Spicy and Aromatic Plants
por: Marc, Romina A., et al.
Publicado: (2023)

Capsaicin-Induced Changes in LTP in the Lateral Amygdala Are Mediated by TRPV1
por: Zschenderlein, Carsten, et al.
Publicado: (2011)

pHluorin-tagged TRPV1 shines light on capsaicin tachyphylaxis
por: Agosti, Francina, et al.
Publicado: (2019)

Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization
por: Puglia, Carmelo, et al.
Publicado: (2020)

The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel
por: Yang, Fan, et al.
Publicado: (2018)

Activation of TRPV1 channel by dietary capsaicin improves visceral fat remodeling through connexin43-mediated Ca(2+) Influx
por: Chen, Jian, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_toq1um49qi1sl0br3k4dnkf330