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Loss of Saltation and Presynaptic Action Potential Failure in Demyelinated Axons

In cortical pyramidal neurons the presynaptic terminals controlling transmitter release are located along unmyelinated axon collaterals, far from the original action potential (AP) initiation site, the axon initial segment (AIS). Once initiated, APs will need to reliably propagate over long distance...

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Detalles Bibliográficos
Autores principales: Hamada, Mustafa S., Popovic, Marko A., Kole, Maarten H. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326753/
https://www.ncbi.nlm.nih.gov/pubmed/28289377
http://dx.doi.org/10.3389/fncel.2017.00045