Transient ALT activation protects human primary cells from chromosome instability induced by low chronic oxidative stress

Cells are often subjected to the effect of reactive oxygen species (ROS) as a result of both intracellular metabolism and exposure to exogenous factors. ROS-dependent oxidative stress can induce 8-oxodG within the GGG triplet found in the G-rich human telomeric sequence (TTAGGG), making telomeres hi...

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Detalles Bibliográficos
Autores principales: Coluzzi, Elisa, Buonsante, Rossella, Leone, Stefano, Asmar, Anthony J., Miller, Kelley L., Cimini, Daniela, Sgura, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327399/
https://www.ncbi.nlm.nih.gov/pubmed/28240303
http://dx.doi.org/10.1038/srep43309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327399/
https://www.ncbi.nlm.nih.gov/pubmed/28240303
http://dx.doi.org/10.1038/srep43309

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