p53 induces miR199a-3p to suppress SOCS7 for STAT3 activation and renal fibrosis in UUO

The role of p53 in renal fibrosis has recently been suggested, however, its function remains controversial and the underlying mechanism is unclear. Here, we show that pharmacological and genetic blockade of p53 attenuated renal interstitial fibrosis, apoptosis, and inflammation in mice with unilater...

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Detalles Bibliográficos
Autores principales: Yang, Ruhao, Xu, Xuan, Li, Huiling, Chen, Jinwen, Xiang, Xudong, Dong, Zheng, Zhang, Dongshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327480/
https://www.ncbi.nlm.nih.gov/pubmed/28240316
http://dx.doi.org/10.1038/srep43409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327480/
https://www.ncbi.nlm.nih.gov/pubmed/28240316
http://dx.doi.org/10.1038/srep43409

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