Enhancing lysosomal biogenesis and autophagic flux by activating the transcription factor EB protects against cadmium-induced neurotoxicity

Cadmium (Cd), a highly ubiquitous heavy metal, is a well-known inducer of neurotoxicity. However, the mechanism underlying cadmium-induced neurotoxicity remains unclear. In this study, we found that Cd inhibits autophagosome-lysosome fusion and impairs lysosomal function by reducing the levels of ly...

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Detalles Bibliográficos
Autores principales: Pi, Huifeng, Li, Min, Tian, Li, Yang, Zhiqi, Yu, Zhengping, Zhou, Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327481/
https://www.ncbi.nlm.nih.gov/pubmed/28240313
http://dx.doi.org/10.1038/srep43466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327481/
https://www.ncbi.nlm.nih.gov/pubmed/28240313
http://dx.doi.org/10.1038/srep43466

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