Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells

BACKGROUND: DNA hypermethylation is a key epigenetic mechanism for the silencing of many genes in cancer. Hinokitiol, a tropolone-related natural compound, is known to induce apoptosis and cell cycle arrest and has anti-inflammatory and anti-tumor activities. However, the relationship between hinoki...

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Detalles Bibliográficos
Autores principales: Seo, Jung Seon, Choi, Young Ha, Moon, Ji Wook, Kim, Hyeon Soo, Park, Sun-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327573/
https://www.ncbi.nlm.nih.gov/pubmed/28241740
http://dx.doi.org/10.1186/s12860-017-0130-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327573/
https://www.ncbi.nlm.nih.gov/pubmed/28241740
http://dx.doi.org/10.1186/s12860-017-0130-3

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