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Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells
BACKGROUND: DNA hypermethylation is a key epigenetic mechanism for the silencing of many genes in cancer. Hinokitiol, a tropolone-related natural compound, is known to induce apoptosis and cell cycle arrest and has anti-inflammatory and anti-tumor activities. However, the relationship between hinoki...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327573/ https://www.ncbi.nlm.nih.gov/pubmed/28241740 http://dx.doi.org/10.1186/s12860-017-0130-3 |