3D: diversity, dynamics, differential testing – a proposed pipeline for analysis of next-generation sequencing T cell repertoire data

BACKGROUND: Cancer immunotherapy has demonstrated significant clinical activity in different cancers. T cells represent a crucial component of the adaptive immune system and are thought to mediate anti-tumoral immunity. Antigen-specific recognition by T cells is via the T cell receptor (TCR) which i...

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Detalles Bibliográficos
Autores principales: Zhang, Li, Cham, Jason, Paciorek, Alan, Trager, James, Sheikh, Nadeem, Fong, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327583/
https://www.ncbi.nlm.nih.gov/pubmed/28241742
http://dx.doi.org/10.1186/s12859-017-1544-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327583/
https://www.ncbi.nlm.nih.gov/pubmed/28241742
http://dx.doi.org/10.1186/s12859-017-1544-9

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