Convection enhanced delivery of panobinostat (LBH589)-loaded pluronic nano-micelles prolongs survival in the F98 rat glioma model

BACKGROUND: The pan-histone deacetylase inhibitor panobinostat is a potential therapy for malignant glioma, but it is water insoluble and does not cross the blood–brain barrier when administered systemically. In this article, we describe the in vitro and in vivo efficacy of a novel water-soluble nan...

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Detalles Bibliográficos
Autores principales: Singleton, WG, Collins, AM, Bienemann, AS, Killick-Cole, CL, Haynes, HR, Asby, DJ, Butts, CP, Wyatt, MJ, Barua, NU, Gill, SS
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327904/
https://www.ncbi.nlm.nih.gov/pubmed/28260886
http://dx.doi.org/10.2147/IJN.S125300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327904/
https://www.ncbi.nlm.nih.gov/pubmed/28260886
http://dx.doi.org/10.2147/IJN.S125300

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