Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease

The polarization of CD4+ T cells into distinct T helper cell lineages is essential for protective immunity against infection, but aberrant T cell polarization can cause autoimmunity. The transcription factor T-bet (TBX21) specifies the Th1 lineage and represses alternative T cell fates. Genome-wide...

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Detalles Bibliográficos
Autores principales: Soderquest, Katrina, Hertweck, Arnulf, Giambartolomei, Claudia, Henderson, Stephen, Mohamed, Rami, Goldberg, Rimma, Perucha, Esperanza, Franke, Lude, Herrero, Javier, Plagnol, Vincent, Jenner, Richard G., Lord, Graham M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328407/
https://www.ncbi.nlm.nih.gov/pubmed/28187197
http://dx.doi.org/10.1371/journal.pgen.1006587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328407/
https://www.ncbi.nlm.nih.gov/pubmed/28187197
http://dx.doi.org/10.1371/journal.pgen.1006587

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