Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria

SCL25A46 is a mitochondrial carrier protein that surprisingly localizes to the outer membrane and is distantly related to Ugo1. Here we show that a subset of SLC25A46 interacts with mitochondrial dynamics components and the MICOS complex. Decreased expression of SLC25A46 results in increased stabili...

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Detalles Bibliográficos
Autores principales: Steffen, Janos, Vashisht, Ajay A., Wan, Jijun, Jen, Joanna C., Claypool, Steven M., Wohlschlegel, James A., Koehler, Carla M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328619/
https://www.ncbi.nlm.nih.gov/pubmed/28057766
http://dx.doi.org/10.1091/mbc.E16-07-0545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328619/
https://www.ncbi.nlm.nih.gov/pubmed/28057766
http://dx.doi.org/10.1091/mbc.E16-07-0545

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