Rapid screening of cellular stress responses in recombinant Pichia pastoris strains using metabolite profiling

Heterologous protein production in the yeast Pichia pastoris can be limited by biological responses to high expression levels; the unfolded protein response (UPR) is a key determinant of the success of protein production in this organism. Here, we used untargeted NMR metabolic profiling (metabolomic...

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Detalles Bibliográficos
Autores principales: Tredwell, Gregory D., Aw, Rochelle, Edwards-Jones, Bryn, Leak, David J., Bundy, Jacob G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Fermentation, Cell Culture and Bioengineering - Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329079/
https://www.ncbi.nlm.nih.gov/pubmed/28160205
http://dx.doi.org/10.1007/s10295-017-1904-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329079/
https://www.ncbi.nlm.nih.gov/pubmed/28160205
http://dx.doi.org/10.1007/s10295-017-1904-5

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