SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity

Cancer stem cells (CSCs) have high tumorigenic capacity. Here, we show that stem-like traits of specific human cancer cells are reduced by overexpression of the histone deacetylase sirtuin 6 (SIRT6). SIRT6-sensitive cancer cells bear mutations that activate phosphatidylinositol-3-kinase (PI3K) signa...

Descripción completa

Detalles Bibliográficos
Autores principales: Ioris, Rafael M., Galié, Mirco, Ramadori, Giorgio, Anderson, Jason G., Charollais, Anne, Konstantinidou, Georgia, Brenachot, Xavier, Aras, Ebru, Goga, Algera, Ceglia, Nicholas, Sebastián, Carlos, Martinvalet, Denis, Mostoslavsky, Raul, Baldi, Pierre, Coppari, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329120/
https://www.ncbi.nlm.nih.gov/pubmed/28228253
http://dx.doi.org/10.1016/j.celrep.2017.01.065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329120/
https://www.ncbi.nlm.nih.gov/pubmed/28228253
http://dx.doi.org/10.1016/j.celrep.2017.01.065

Ejemplares similares