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Enhanced Efficacy of 5-Fluorouracil in Combination with a Dual Histone Deacetylase and Phosphatidylinositide 3-Kinase Inhibitor (CUDC-907) in Colorectal Cancer Cells

BACKGROUND/AIMS: 5-Fluorouracil (5-FU) is widely used in the treatment of patients with colorectal cancer (CRC). However, the efficacy of 5-FU as a single agent is limited, with multiple undesired side effects. Therefore, the aim of the current study was to assess the efficacy of CUDC-907 (a dual in...

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Detalles Bibliográficos
Autores principales: Hamam, Rimi, Ali, Dalia, Vishnubalaji, Radhakrishnan, Alsaaran, Zaid F., Chalisserry, Elna Paul, Alfayez, Musaad, Aldahmash, Abdullah, Alajez, Nehad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329975/
https://www.ncbi.nlm.nih.gov/pubmed/28139498
http://dx.doi.org/10.4103/1319-3767.199136