Non-traumatic keratitis due to Colletotrichum truncatum

INTRODUCTION: The fungal genus Colletotrichum is an uncommon cause of human infections. It has been implicated in cutaneous phaeohyphomycosis, artritis and keratitis secondary to traumatic implantation. CASE PRESENTATION: We report two cases of keratitis due Colletotrichum truncatum in middle-aged,...

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Detalles Bibliográficos
Autores principales: Llamos, Reina, Al-Hatmi, Abdullah M. S., Martínez, Gerardo, Hagen, Ferry, Velar, Rosario, de la Caridad Castillo Pérez, Alexeide, Meis, Jacques F., Illnait-Zaragozí, María T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330238/
https://www.ncbi.nlm.nih.gov/pubmed/28348770
http://dx.doi.org/10.1099/jmmcr.0.005047
Descripción
Sumario:INTRODUCTION: The fungal genus Colletotrichum is an uncommon cause of human infections. It has been implicated in cutaneous phaeohyphomycosis, artritis and keratitis secondary to traumatic implantation. CASE PRESENTATION: We report two cases of keratitis due Colletotrichum truncatum in middle-aged, immunocompetent persons without history of trauma. The aetiological agents were identified based on DNA sequencing. Azoles and echinocandins showed high minimal inhibitory concentrations while amphotericin B was ≤ 0.25  mg l(−1). Both patients failed topical antifungal treatment and needed penetrating keratoplasty with a favourable outcome. CONCLUSION: C. truncatum caused keratomycosis which did not respond to topical antifungal agents. To the best of our knowledge these are the first reported cases of keratitis due to this fungus in Cuba and Latin-America and highlights the expanding spectrum of fungal agents causing eye infections.