SHP‐2 Phosphatase Prevents Colonic Inflammation by Controlling Secretory Cell Differentiation and Maintaining Host‐Microbiota Homeostasis

Polymorphisms in the PTPN11 gene encoding for the tyrosine phosphatase SHP‐2 were described in patients with ulcerative colitis. We have recently demonstrated that mice with an intestinal epithelial cell‐specific deletion of SHP‐2 (SHP‐2(IEC‐KO)) develop severe colitis 1 month after birth. However,...

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Detalles Bibliográficos
Autores principales: Coulombe, Geneviève, Langlois, Ariane, De Palma, Giada, Langlois, Marie‐Josée, McCarville, Justin L., Gagné‐Sanfaçon, Jessica, Perreault, Nathalie, Feng, Gen‐Sheng, Bercik, Premysl, Boudreau, François, Verdu, Elena F., Rivard, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330278/
https://www.ncbi.nlm.nih.gov/pubmed/27100271
http://dx.doi.org/10.1002/jcp.25407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330278/
https://www.ncbi.nlm.nih.gov/pubmed/27100271
http://dx.doi.org/10.1002/jcp.25407

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