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The impact of RNA secondary structure on read start locations on the Illumina sequencing platform
High-throughput sequencing is subject to sequence dependent bias, which must be accounted for if researchers are to make precise measurements and draw accurate conclusions from their data. A widely studied source of bias in sequencing is the GC content bias, in which levels of GC content in a genomi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330537/ https://www.ncbi.nlm.nih.gov/pubmed/28245230 http://dx.doi.org/10.1371/journal.pone.0173023 |