The Ca(2+) sensitizer CK‐2066260 increases myofibrillar Ca(2+) sensitivity and submaximal force selectively in fast skeletal muscle

KEY POINTS: We report that the small molecule CK‐2066260 selectively slows the off‐rate of Ca(2) (+) from fast skeletal muscle troponin, leading to increased myofibrillar Ca(2) (+) sensitivity in fast skeletal muscle. Rodents dosed with CK‐2066260 show increased hindlimb muscle force and power in re...

Descripción completa

Detalles Bibliográficos
Autores principales: Hwee, Darren T., Cheng, Arthur J., Hartman, James J., Hinken, Aaron C., Lee, Ken, Durham, Nickie, Russell, Alan J., Malik, Fady I., Westerblad, Håkan, Jasper, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Muscle
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330873/
https://www.ncbi.nlm.nih.gov/pubmed/27869319
http://dx.doi.org/10.1113/JP273248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330873/
https://www.ncbi.nlm.nih.gov/pubmed/27869319
http://dx.doi.org/10.1113/JP273248

Ejemplares similares