Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat

Ribozyme genes were designed to reduce voluntary alcohol drinking in a rat model of alcohol dependence. Acetaldehyde generated from alcohol in the liver is metabolized by the mitochondrial aldehyde dehydrogenase (ALDH2) such that diminishing ALDH2 activity leads to the aversive effects of blood acet...

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Detalles Bibliográficos
Autores principales: Sapag, Amalia, Irrazábal, Thergiory, Lobos-González, Lorena, Muñoz-Brauning, Carlos R, Quintanilla, María Elena, Tampier, Lutske
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330938/
https://www.ncbi.nlm.nih.gov/pubmed/27404720
http://dx.doi.org/10.1038/mtna.2016.41

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330938/
https://www.ncbi.nlm.nih.gov/pubmed/27404720
http://dx.doi.org/10.1038/mtna.2016.41

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