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Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
How can tissues generate large numbers of cells, yet keep the divisional load (the number of divisions along cell lineages) low in order to curtail the accumulation of somatic mutations and reduce the risk of cancer? To answer the question we consider a general model of hierarchically organized self...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331224/ https://www.ncbi.nlm.nih.gov/pubmed/28230094 http://dx.doi.org/10.1038/ncomms14545 |