VEGFA activates an epigenetic pathway upregulating ovarian cancer‐initiating cells

The angiogenic factor, VEGFA, is a therapeutic target in ovarian cancer (OVCA). VEGFA can also stimulate stem‐like cells in certain cancers, but mechanisms thereof are poorly understood. Here, we show that VEGFA mediates stem cell actions in primary human OVCA culture and OVCA lines via VEGFR2‐depen...

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Detalles Bibliográficos
Autores principales: Jang, Kibeom, Kim, Minsoon, Gilbert, Candace A, Simpkins, Fiona, Ince, Tan A, Slingerland, Joyce M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331266/
https://www.ncbi.nlm.nih.gov/pubmed/28179359
http://dx.doi.org/10.15252/emmm.201606840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331266/
https://www.ncbi.nlm.nih.gov/pubmed/28179359
http://dx.doi.org/10.15252/emmm.201606840

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