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Continuous N-alkylation reactions of amino alcohols using γ-Al(2)O(3) and supercritical CO(2): unexpected formation of cyclic ureas and urethanes by reaction with CO(2)
The use of γ-Al(2)O(3) as a heterogeneous catalyst in scCO(2) has been successfully applied to the amination of alcohols for the synthesis of N-alkylated heterocycles. The optimal reaction conditions (temperature and substrate flow rate) were determined using an automated self-optimising reactor, re...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331277/ https://www.ncbi.nlm.nih.gov/pubmed/28326142 http://dx.doi.org/10.3762/bjoc.13.36 |